EXPLORATION OF PEROVSKIA ABROTANOIDES KAR. OILS: ANTIMICROBIAL AND ANTIOXIDENT EFFECTS

Abstract

ackground: Perovskia abrotanoides, a medicinal plant indigenous to the Baluchistan province and northern regions of Pakistan, is renowned for its therapeutic properties. Despite its widespread traditional use, comprehensive data on its chemical composition and biological properties are lacking.
Objective: This study aimed to elucidate the chemical composition and biological activities of essential and fixed oils extracted from Perovskia abrotanoides, focusing on antioxidant and antimicrobial properties.
Methods: Gas Chromatography-Mass Spectrometry (GC-MS) analysis was employed to identify chemical constituents. Antioxidant activity was assessed using DPPH radical scavenging assay, linoleic acid peroxidation inhibition assay, and reducing power assay. Antimicrobial activity was evaluated using the disc diffusion method and Minimum Inhibitory Concentration (MIC) determination. In vivo studies on animal models were conducted to assess antioxidant and antimicrobial effects.
Results: The study revealed diverse chemical compositions in the essential and fixed oils extracted from stems and leaves. Essential oils exhibited significant antioxidant activity, with variations observed between stem and leaves. Fixed oils also showed antioxidant potential, albeit to a lesser extent. Antimicrobial activity varied across microorganisms, with notable inhibition observed against specific strains.
Conclusion: Perovskia abrotanoides oils exhibit promising antioxidant and antimicrobial properties, suggesting their potential as natural remedies. Further research is needed to identify specific bioactive compounds and explore their therapeutic applications