Acute Flares of Chronic Hepatitis B (AFOCHB): A Small Review

Authors

DOI:

https://doi.org/10.5281/zenodo.7669478%20

Keywords:

Liver Disease, Chronic Hepatitis B, Treatment, Virus, Patients

Abstract

Acute flares of chronic hepatitis B (AFOCHB) is defined as an acute disease characterized by sudden rise of levels of alanine aminotransferase (ALT) five times higher than the upper limit of normal values in a patient suffering from chronic hepatitis B virus (HBV) infection. It can occur in association various disorders and represents a serious condition which requires immediate treatment in order to avoid serious complications, even lethal. This review summarizes the advances in diagnosis and treatment of Acute flares of chronic hepatitis B, AFOCHB.

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References

Bestas, R., & Yalcin, K. (2021). Clinical and Virological Features of Acute Hepatic Exacerbations in Patients With Chronic Hepatitis B Virus Infection. Cureus, 13(6).

Bonino, F., & Brunetto, M. R. (2003). Chronic hepatitis B e antigen (HBeAg) negative, anti-HBe positive hepatitis B: an overview. Journal of hepatology, 39, 160-163.

Bortolotti, F., Cadrobbi, P., Crivellaro, C., Guido, M., Rugge, M., Noventa, F., ... & Realdi, G. (1990). Long-term outcome of chronic type B hepatitis in patients who acquire hepatitis B virus infection in childhood. Gastroenterology, 99(3), 805-810.

Cannizzaro, M. V., Franceschini, C., Esposito, M., Bianchi, L., & Giunta, A. (2017). Hepatitis B reactivation in psoriasis patients treated with anti-TNF agents: prevention and management. Psoriasis: Targets and Therapy, 35-40.

Chan, H. L. Y., Hui, Y., Leung, N. W. Y., Ching, J. Y. L., Chan, F. K. L., & Sung, J. J. Y. (2000). Risk factors for active liver disease in HBeAg-negative chronic hepatitis B virus–infected patients. The American journal of gastroenterology, 95(12), 3547-3551.

Chang, M. L., & Liaw, Y. F. (2014). Hepatitis B flares in chronic hepatitis B: pathogenesis, natural course, and management. Journal of hepatology, 61(6), 1407-1417.

Chronic Hepatitis B patients. Clinical Immunology, 128(3), 400-408.

CHU, C. M., & LIAW, Y. F. (1997). Natural history of chronic hepatitis B virus infection: an immunopathological study. Journal of gastroenterology and hepatology, 12(9‐10), S218-S222.

Emori CT, Perez RM, Matos CA, Uehara SN, Pereira Pda S, Feldner (2014) Acute exacerbation of chronic hepatitis B virus infection in renal transplant patients. Braz J Infect Dis.18 (6):625-30

Flink, H. J., Sprengers, D., Hansen, B. E., van Zonneveld, M., De Man, R. A., Schalm, S. W., & Janssen, H. L. A. (2005). Flares in chronic hepatitis B patients induced by the host or the virus? Relation to treatment response during Peg-interferon α-2b therapy. Gut, 54(11), 1604-1609.

Gao, L., Wang, J. F., Xiang, M., Fan, Y. C., Zhang, Z. G., & Wang, K. (2011). Expression of human glucocorticoid receptor in T lymphocytes in acute-on-chronic hepatitis B liver failure. Digestive diseases and sciences, 56, 2605-2612.

Giles, M., Visvanathan, K., Lewin, S., Bowden, S., Locarnini, S., Spelman, T., & Sasadeusz, J. (2015). Clinical and virological predictors of hepatic flares in pregnant women with chronic hepatitis B. Gut, 64(11), 1810-1815.

Holmes, J. A., Yu, M. L., & Chung, R. T. (2017). Hepatitis B reactivation during or after direct acting antiviral therapy–implication for susceptible individuals. Expert opinion on drug safety, 16 (6), 651-672.

Huang, Y. H., Hsiao, L. T., Hong, Y. C., Chiou, T. J., Yu, Y. B., Gau, J. P.,& Lee, S. D. (2013). Randomized controlled trial of entecavir prophylaxis for rituximab-associated hepatitis B virus reactivation in patients with lymphoma and resolved hepatitis B. J Clin Oncol, 31 (22), 2765-2772.

Hung, H. H., Su, C. W., Wu, J. C., & Lee, S. D. (2010). Reactivation of hepatitis B virus after transarterial chemo-embolization for hepatocellular carcinoma in one patient with negative hepatitis B surface antigen. Journal of hepatology, 52(3), 463-465.

Kumar, M., Chauhan, R., Gupta, N., Hissar, S., Sakhuja, P., & Sarin, S. K. (2009). Spontaneous increases in alanine aminotransferase levels in asymptomatic chronic hepatitis B virus-infected patients. Gastroenterology, 136(4), 1272-1280.

Liang, J., Liu, L., Cao, Y., Zhang, Q., Liu, F., Chen, Y., ... & Han, T. (2021). Hepatitis B-related acute-on-chronic liver failure induced by hepatotropic viral insult is associated with worse prognosis than that induced by non-virus insult. BMC Infectious Diseases, 21(1), 1-12.

Liaw, Y. F. (2009). HBeAg seroconversion as an important end point in the treatment of chronic hepatitis B. Hepatology international, 3, 425-433.

Liaw, Y. F., Pao, C. C., & Chu, C. M. (1988). Changes of serum HBV‐DNA in relation to serum transaminase level during acute exacerbation in patients with chronic type B hepatitis. Liver, 8(4), 231-235.

Liaw, Y. F., Tai, D. I., Chu, C. M., Pao, C. C., & Chen, T. J. (1987). Acute exacerbation in chronic type B hepatitis: comparison between HBeAg and antibody‐positive patients. Hepatology, 7(1), 20-23.

Lok, A. S., Liang, R. H., Chiu, E. K., Wong, K. L., Chan, T. K., & Todd, D. (1991). Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy: report of a prospective study. Gastroenterology, 100 (1), 182-188.

Maruyama, T., McLachlan, A., Iino, S., Koike, K., Kurokawa, K., & Milich, D. R. (1993). The serology of chronic hepatitis B infection revisited. The Journal of clinical investigation, 91(6), 2586-2595.

Oliveri, F., Coco, B., Ciccorossi, P., Colombatto, P., Romagnoli, V., Cherubini, B., ... & Brunetto, M. R. (2008). Liver stiffness in the hepatitis B virus carrier: a non-invasive marker of liver disease influenced by the pattern of transaminases. World journal of gastroenterology: WJG, 14(40), 6154.

Park, J. W., Kwak, K. M., Kim, S. E., Jang, M. K., Kim, D. J., Lee, M. S., ... & Park, C. K. (2015). Differentiation of acute and chronic hepatitis B in IgM anti-HBc positive patients. World Journal of Gastroenterology: WJG, 21(13), 3953.

Perrillo, R. P. (2001). Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease. Gastroenterology, 120 (4), 1009-1022.

Seeff, L. B., & Koff, R. S. (1986, February). Evolving concepts of the clinical and serologic consequences of hepatitis B virus infection. In Seminars in liver disease (Vol. 6, No. 01, pp. 11-22). © 1986 by Thieme Medical Publishers, Inc.. (Seeff LB and Koff RS 1986)

Tassopoulos, N. C., Papaevangelou, G. J., Sjogren, M. H., Roumeliotou-karayannis, A., Gerin, J. L., & Purcell, R. H. (1987). Natural history of acute hepatitis B surface antigen-positive hepatitis in Greek adults. Gastroenterology, 92 (6), 1844-1850.

Wang, K., Liu, H., He, Y., Chen, T., Yang, Y., Niu, Y., ... & Zhao, Y. (2010). Correlation of TLR1-10 expression in peripheral blood mononuclear cells with chronic hepatitis B and chronic hepatitis B-related liver failure. Human immunology, 71(10), 950-956.

Yeo, W., Zee, B., Zhong, S., Chan, P. K. S., Wong, W. L., Ho, W. M., & Johnson, P. (2004). Comprehensive analysis of risk factors associating with Hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy. British Journal of Cancer, 90 (7), 1306-1311.

Yoon, Y. M., Kang, D. Y., Kim, D. Y., Seo, J. W., Lim, H. J., Lee, H. J., & Park, S. G. (2016). Extremely elevated alpha-fetoprotein due to acute exacerbation of chronic hepatitis B without malignancy: a case report. Journal of Medical Case Reports, 10(1), 1-4.

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Published

2023-04-16
CITATION
DOI: 10.5281/zenodo.7669478
Published: 2023-04-16

How to Cite

Filippo Manelli, & Maria Sofia Cotelli. (2023). Acute Flares of Chronic Hepatitis B (AFOCHB): A Small Review. Pakistan’s Multidisciplinary Journal for Arts & Science, 4(01), 65 –. https://doi.org/10.5281/zenodo.7669478

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