Formulation Development and Characteristics Assessment of Metronidazole Tablets (Colon Specific Coated)
Keywords:Colon Drug Delivery, Metronidazole, Polymer, Eudragit, Guar Gum
The system of drug delivery mainly depends on targeted therapy synthesis that is the formulations active pharmaceuticals ingredients from drug will only be released target area, so the action generated by active pharmaceutical ingredients in specific time period depends on formulation of drug therapy. Colon specified drug targeted system either in the form of polymers or in single can be used to obtain the desired and needed therapeutic effect. FTIR were done of active ingredient (Metronidazole and polymers separately and their combination), pre-compression tests (Flowability, Angle of response, compressibility index and Hansner’s ratio) were also performed. Solubility studies were also performed with different solvents and temperatures. Two different formulations were prepared F1 and F2 with different drug to polymer ratios were combined by coating two different types of polymers Eudragit and Guar gum. All physical characteristics of both formulations F1 and F2 were performed accordingly and in-vitro dissolution were also done. The results showed that there is no compatibility with drug and polymers. The drug is highly soluble in distilled water. The pre-compression results were within the acceptable range. Both the Formulation F1 and F2 physical characteristics were within the specified limits. The dissolution results of both formulations F1 and F2 showed the absorption of polymer greater from (F1) to (F2) w/w, the drug rate release same comparatively. Comparatively extent of release of drug was observed. It is concluded that this type of research may be conducted for patient bifacial and compliance.
Alkazzaz, S. Z. M. and W. K. Ali (2015). "Design and in-vitro evaluation of colon targeted prednisolone solid dispersion tablets." Pharmaceutical and Biosciences Journal: 30-41.
Godwin, A., Bolina, K., Clochard, M., Dinand, E., Rankin, S., Simic, S., & Brocchini, S. (2001). New strategies for polymer development in pharmaceutical science—a short review. Journal of Pharmacy and Pharmacology, 53(9), 1175-1184.
Hassan, B. A. R. (December 10, 2012). Overview on Drug Delivery System. Pharmaceut Anal Acta.
Kumar, M. P., et al. (2011). "Formulation and evaluation of colon specific matrix and coated tablet of metronidazole." Int Res J Pharm 2(9): 194-199.
Kumar, S. P., et al. (2012). "Novel colon specific drug delivery system: A Review." Int J Pharm Pharm Sci 4(Suppl 1): 22-29.
Mehta, R., et al. (2013). "Formulation and in vitro evaluation of Eudragit S-100 coated pharmaceutical technology & research 4(1): 31.
naproxen matrix tablets for colon-targeted drug delivery system." Journal of advanced Khirwadkar, P., & Dashora, K. (2003). Formulation and evaluation of fast dissolving tablets Atenolol. Journal of Chemical and Pharmaceutical Research, 6(2), 113-119.
Patel, M. M. and A. F. Amin (2011). "Formulation and development of release modulated colon targeted system of meloxicam for potential application in the prophylaxis of colorectal cancer." Drug delivery 18(4): 281-293.
Patel, R., et al. (2010). "Design Optimization and Evaluation of pH Responsive Prednisolone Sustained Release Tablet for Ileo-colonic Delivery."
Raizada, A. Polymers in drug delivery: a review.
Rajpurohit, H., Sharma, P., Sharma, S., & Bhandari, A. (2010). Polymers for Colon Targeted Drug Delivery (Vol. 72).
Rani, K., & Paliwal, S. (2014). A review on targeted drug delivery: Its entire focus on advanced therapeutics and diagnostics. Sch. J. App. Med. Sci, 2(1C), 328-331.
Sharma, M., et al. (2012). "Formulation and evaluation of colon targeted tablets of mesalazine." Journal of Drug Delivery and Therapeutics 2(5).
Singh, S. and A. K. Mahato (2016). "Formulation and evaluation of metronidazole tableted microspheres for colon drug delivery." Asian Journal of Pharmaceutical and Clinical Research: 398-403.
Sonje, A., & Chandra, A. (2013). Comprehensive review on Eudragit polymers. Int Res J Pharm, 4(5), 71-74.
Swati, A., Achhrish, G., & Sandeep, S. (2012). Drug delivery: special emphasis given on biodegradable polymers. Adv Polym Sci Technol, 2, 1-15.
Vyas, S., & Khar, R. (2002). Systems for colon specific delivery. Controlled drug delivery: Concept and advantages. 1st ed. Delhi: Vallabh Prakashan, 218-256.